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- Functionalization of nanotubes
- Organiic synthesis
- Polyelectrolytes
- TEM imaging

Environmental chemistry:

- Analysis of pollutants
- Purification methods
- Soil and water samples


Research Areas

- Toxicology
- Energy Sciences
- Pollution dynamics
- Water pollution circulation
- Life cycle of pollutants
- Heavy Metals
- Molecular interactions
- Environmental remediation
- Waste management
- Exotic Materials



Fjordforsk A.S. Midtun, 6894 Vangsnes, Norway. 911659654 |

Computational profiling of PFC-susceptible proteins in the human proteome.


Collaborating Institute:

The University of Uppsala, Science of Life Laboratory. Dept. of Cell & Molec. Biol., Uppsala University. Box 596, 75124 Uppsala, Sweden.

Project leader. Prof D. van der Spoel.

Project duration: 2016 -


Project description:

Perfluorinated compounds are emerging pollutants which have been released in the environment for decades, and have been recently found to accumulate in bioorganisms, fish, animals, humans, and entire food-chains. Given their persistent chemistry, PFCs have raised concern in the ecotoxicology field and call for more studies, given their suspected effects in causing cancer, neurotoxicity, infertility and other, recently emerging toxic effects. This project devices the use of supercomputers to perform a high-count proteomic analysis of the chemistry of interaction between PFCs and serological, cellular and other biological factors associated with the path of exposure to PFCs for multicellular organisms, in order to reveal and study the accurate modes of toxicity that PFCs cause on living organisms.



Keywords. Supercomputers, PFOS, perfluorinated compounds, biochemistry, molecular toxicology mechanisms, GROMACS, REACH, EHS.


Participants: Manzetti S., van der Spoel D., Ghahremanpour M.




Manzetti S. (2017). Bonding of Butylparaben, Bis(2-ethylhexyl)-phthalate, and Perfluorooctanesulfonic Acid to DNA: Comparison with Benzo[a]pyrene Shows Low Probability for Strong Noncovalent DNA Intercalation. Chemical Research in Toxicology, in press.

Yildirim A, Zhang J, Manzetti S and van der Spoel D. (2016): Binding of Pollutants to Biomolecules - A Simulation Study. Chem. Res. Toxicol., DOI: 0.1021/acs.chemrestox.6b00189. In press



Figure. Electrostatic properties of the perfluorooctanatesulfonic acid molecule. Click to enlarge.













Ongoing programs



Industrial Doctorate program in Environmental Chemistry at Uppsala University.

Dr. Phil. program in Mathematics at University of Oslo.

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